Development of Platform Technology

To date, electron microscopy is still largely used akin to X-ray crystallography, that is on highly purified and static samples arrested e.g. by non-hydrolysable nucleotides. However, while more complicated to work with, dynamic samples often tell the more interesting (biological) story. Consequently, we are trying to advance methods to work with these samples, focussing on applying timed light pulses to the sample to then trap activated states by rapid vitrification.